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Previously we showed that MS
2020-11-12
Previously, we showed that MS-10, a combined extract of Cirsium japonicum var. Maackii (Maxim.) Matsum. (Korean milk thistle) and Thymus vulgaris L., increases the efficiency of estrogen in the estrogen-deficient state by activating the estrogen receptor (ER). MS-10 increased bone mineral density (B
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br Materials and methods br Results br Discussion UPP
2020-11-12
Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important pitavastatin of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the phosphorylation sy
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The photocleaving properties of were studied by
2020-11-11
The photocleaving properties of 1 were studied by performing ΦX174 photocleavage assays. Light irradiation of the mixtures of increasing amounts of 1 with supercoiled DNA caused>90% supercoiled form relaxation and approximately 5% of linearization for the higher concentrations of 1 (1:10bp and 1:2bp
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In order to derive a better understanding of the
2020-11-11
In order to derive a better understanding of the results from our SAR study, we utilized Glide to model the binding of the SAR compounds with the non-active site pocket of TS-DHFR shown in C. The majority of models position the phenolic moiety of these compounds within the non-active site pocket, wh
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Preparation of the regioisomeric pyridooxazepinones and was
2020-11-11
Preparation of the regioisomeric pyridooxazepinones 10 and 11 was accomplished utilizing the synthetic sequence depicted in Scheme 3. Amide coupling of 63 and ZD 7288 chloride 64 afforded amide 65. Removal of the alcohol protecting group, followed by base catalyzed cyclization afforded a 1:2.4 mixt
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br CDKs as Direct Coactivators
2020-11-11
CDKs as Direct Coactivators of Proinflammatory Transcription Factors CDKs fuel inflammation by triggering the function of proinflammatory transcription factors such as NF-κB, STAT3, and AP-1. This is achieved at two levels because CDKs can affect gene expression by targeting global transcription
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Crystal structures of various CRM complexes have provided
2020-11-11
Crystal structures of various CRM1 complexes have provided insight into molecular details of the interactions between CRM1 and its interaction partners during the transport cycle. CRM1 cooperatively binds RanGTP and cargo in the nucleus (Paraskeva et al., 1999). In this ternary complex, RanGTP is l
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br Acknowledgements The study was supported by
2020-11-11
Acknowledgements The study was supported by grant no. 501-003-11043 from the Institute of Psychiatry and Neurology in Warsaw. The authors thank Mrs. Ala Biegaj for the excellent technical assistance. Introduction In an effort to identify hIFN receptor molecules encoded by a gene(s) within hum
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In rats exposed to day of nicotine withdrawal
2020-11-11
In rats exposed to 1 day of nicotine withdrawal (24 h after the last nicotine administration) we expected a decrease of general locomotor activity and a decrease of global striatal dopamine release, which were assessed in a previous study following 14 days of nicotine exposure and 24 h of nicotine w
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br Results br Discussion Drug resistance poses the
2020-11-11
Results Discussion Drug resistance poses the greatest hurdle of achieving high efficacy with AADs in cancer patients. AAD-treated cancer patients often encounter intrinsic and evasive drug resistance that diminishes the therapeutic efficacy to only minor survival benefits in most cancer types.
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The present findings suggested that nsEP
2020-11-11
The present findings suggested that nsEP inhibited CPG2 via deprivation of zinc ions, with no effect on apoenzyme integrity. Zinc may be removed from CPG2 by the electric forces. Within CPG2, each zinc ion was coordinated by one histidine, one glutamate and one aspartate [6]. The nsEP field can alt
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Pahlavanzadeh and Fakouri Baygi employed PC SAFT EoS
2020-11-11
Pahlavanzadeh and Fakouri-Baygi [6] employed PC-SAFT EoS to predict the phosphocreatine synthesis of carbon dioxide by aqueous MEA solutions. They used the ideal form of Smith–Missen algorithm to calculate liquid phase concentrations. The results illustrate acceptable accuracies so that the AAD was
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br Multi hierarchical structure of collagen Protein structur
2020-11-11
Multi-hierarchical structure of collagen Protein structure is the foundation of protein functions and properties. It is generally accepted that the protein has biological function only when it has tertiary structure or above. Among the identified 28 types of collagen, most is known about type I c
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br Materials and methods br Results br
2020-11-11
Materials and methods Results Discussion This study demonstrates that various progestogens combined with E2 had different effects on breast cell growth. These effects had an inverse correlation with the changes of the PRA/PRB ratio. E2's antiapoptotic effects on MCF-7 abiraterone acetate ma
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br Conflict of interest statement
2020-11-10
Conflict of interest statement Acknowledgement The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 278742 (Eurosarc) Introduction Pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like
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